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Acupuncture While the evidence base is mixed, acupuncture has shown benefits for various neuropathic pain conditions

PLoS ONE 3 , e3898 (2008)

This heterogeneity complicates the development of universal therapeutic strategies, as different PF subtypes may require customized approaches

Elderly, Cachectic, or Debilitated Patients: Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients (see WARNINGS, Life-Threatening Respiratory Depression)